Sentence examples for requirement for complementarity from inspiring English sources
To eliminate the potential misleading influence of these sequences, which may be under selection due to the requirement for complementarity between miRNAs and their targets, on the similarity test, each foldback arm with hits (E<0.05) in the FASTA search was analyzed independently with and without the miRNA or miRNA-complementary sequences.
However, the requirement for complementarity of only seven or eight nucleotides could result in hundreds of possible targets (Lim et al, 2005).
Each CRISPR spacer, however, is in principle constrained to target a specific phage because of the requirement for complementarity to the entire RNA sequence (though see below on the possibility of CRISPR seed sequence).
Binding of the 5' end of the guide strand to the target mRNA appears to be critical, with an almost absolute requirement for complementarity at the so-called "seed site" from positions 2 7 (measuring from the 5' end of the guide strand) [ 9- 11].
This would indicate that, whilst hydrophobic interactions between this portion of the inhibitor and protein would appear to be important, there is also a requirement for shape complementarity.
This will in part reflect the requirement for domain complementarity but as we illustrate here, there has also been a selective adaptation of the structures of conformationally vulnerable molecules to favour intermolecular linkage, as a defensive response to the exposure of active and potentially toxic β-interfaces.
In contrast, there is currently no evidence for a seed sequences in piRNAs and current evidence points to a requirement for nearly complete complementarity over the full length of the piRNA for targeting.
Both the rapid evolution of viruses and the necessity of precise gene regulation could have worked as selective pressures towards the modern miRNA pathway since the requirement for a high degree of complementarity between plant miRNAs and their targets can act as a stabilizer, preventing sequence drift even over long periods of evolutionary time [ 43].
Look for complementarity between apparently sharply differing viewpoints, she suggests.
Sometimes Hacker lobbies for similarity as his ideal criterion, at other times for complementarity.
So, look for complementarity.
