IT is not an easy task to give the Christmas Lectures at the Royal Institution, especially on a subject like physiology, in which experiments are much more difficult than in some others, at least when required to work without fail, to be intelligible and not to cause offence.
Even within the variability of our recorded values of L-SR junctional widths and extension, our results suggest that localized [Ca 2+] transients due to junctional Ca 2+ release can without fail reach values required to breach the threshold for CICR from junctional RyR3s.
If he is clunking around for four hours in the gym, which he does every day without fail, then he requires somewhere nearer to 9,000 or 10,000 calories, rising to 12,000 as a competition approached.
I once had a job that required eating dinner at work once a week, and without fail our boss, with fingers he literally would have just pulled out of his nose or ear, would grab food from the serving bowls!
Her job requires less after-hours entertaining than mine, meaning she is without fail the one who rushes home from work to look after the kids.
The classes always require you to think on your feet: although I've taught it for many years, without fail students will manage to ask a question that I haven't thought about before.
When the times comes to pivot (and it will, sooner or later, without fail) organizations in "Stay the course!" mode will not be able to pivot as fast, because pivoting requires making a previous choice wrong.
"Almost every night, without fail, he would be home by 7 p.m. to have dinner with the family, and he would always require us to spend time together on Sunday," recalls Alexander Lo, 28.
I failed miserably, without fail.
Without fail, that worked.
