Bacteria require virulence factors to colonize, multiply and survive in the udder.
Pedestal formation requires virulence-related EHEC proteins to be injected directly into the host cell through a type III secretion system (TTSS) [8].
Therefore, some F. tularensis factors required for virulence in mammals are also required for virulence in the arthropod model system, but there are distinct molecular differences utilized by F. tularensis to exploit the two hosts [22], [23].
Here we show that unsaturation in C8 and methylation in C9 is required for virulence in the mouse model without affecting fungal growth in vitro or common virulence factors.
CPS is required for virulence of bacteria and variation in CPS content may contribute to the differences in virulence among A. pleuropneumoniae isolates [38].
Virulence studies utilizing systemic models of infection showed that a full-length RopB was required for virulence.
To identify genes required for virulence that could be used as targets for novel treatments, we mapped quantitative trait loci (QTL) affecting virulence in the progeny of a cross between two strains of A. nidulans (FGSC strains A4 and A91).
TLR signaling is required for virulence of an intracellular pathogen.
Coyne, M.J. et al. Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilis.
Many PA14 factors are required for virulence in more than one of these hosts.
