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Significant capital is required upfront to get ventures off the ground.
Ms. Taylor said she hired relatives and trusted friends, saying that otherwise payment would have been required upfront.
"I'm not sure we could exist at all if we were required upfront to have F.D.A. approval," Randy Scott, the chief executive of Genomic Health, said in an interview earlier this year.
There are exceptions for required upfront mortgage insurance premiums, say for a Federal Housing Administration loan, and for points that borrowers elect to pay to lower the mortgage interest rate.
Borrowers considering loan assumption should weigh the costs against other loan options, paying attention to the principal and interest payment, the amount of cash required upfront, and the private mortgage insurance premium.
But others have more justified qualms about the federal borrowing required upfront to make up for the money diverted away from the system into private accounts—some $750 billion over the next decade, by the White House's calculations, and rather more in the decades thereafter.
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This requires upfront investments to help doctors convert.
Some policies handle billing for hospital expenses, particularly helpful since overseas hospitals often require upfront payment.
Conventional loans, which conform to Fannie and Freddie underwriting guidelines, do not require upfront mortgage insurance.
He wants to reform the benefits system but this will require upfront costs of, according to Labour, £7bn.
The bailout did not require upfront money from the government, and the world avoided an even bigger financial crisis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com