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We argue that a new generation of holonic energy systems is required to orchestrate the interplay between these dense, diverse and distributed energy components.
Here, we use the immune system as a model to demonstrate the complex interplay between transcription factors and the chromatin landscape required to orchestrate precise gene responses to external stimuli and further to demonstrate how these interactions can establish memory of past transcriptional events.
A draft plan covering the flight logistics and what sort of personnel would be required to orchestrate the hand-off was included in the documents.
While a Rac1-independent program contributes to skin and oral mucosal development and its homeostasis, a Rac1-dependent program may be strictly required to orchestrate the tissue response to injury and ultimate for wound closure.
It is possible that more focused analysis may reveal additional expression in the fin bud, but most probably the array of potential cis-acting regulatory elements chosen in this study did not cover the complete toolbox of elements required to orchestrate gli3 expression during zebrafish development.
The degree of overlap between profiles of REST and CoREST targets during these OL developmental transitions, particularly the final transition, suggests that highly complex and integrated transcriptional regulatory mechanisms involving REST and CoREST are required to orchestrate the expression of genes involved in OL maturation and maintenance.
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I can only imagine the level of visibility that Santa requires to orchestrate purchase orders, shipments, in transit inbound inventory of raw materials and components, and the optimization of the transportation network to get all his supplies to the North Pole on time.
The specialized skills required to successfully orchestrate and manage an outsourcing agenda need to be cultivated and nurtured as an integral part of a management curriculum.
Here, we outline novel insights and perspectives regarding the function of Polycomb complexes in shaping the stem cell genome architecture, and discuss how this function might be required to properly orchestrate transcriptional programs during differentiation.
Variations in the remaining BH3 sequence provide the specificity required to precisely orchestrate the interactions within the BCL-2 family members.[ 384, 385] Proteins of the BCL-2 family are considered targets of high interest in drug development, and their modulation has been addressed by different approaches.
The skills required to assemble, orchestrate, manage, and catalyze these relationships are sufficiently specialized that Cambridge University is now offering a four-day course for "partnership brokers". According to the website, a partnership broker is "someone who works as an intermediary building effective and innovative collaboration" in non-traditional partnerships and cross-sectoral networks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com