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We believe the observation that more dynein is required to observe a similar density of runs in the absence of Bik1 and Lis1 reflects the fact that, in the presence of Kip2, there are fewer microtubule binding sites available to dynein since Kip2 and dynein compete for the same site on the microtubule.
The idea that inactivation of several RB family members may be required to observe a strong phenotype during HCC development is supported by the observation that most of the events known to inactivate the RB pathway are upstream events and may inactivate RB, p107, and p130 simultaneously [65], [66], [67], [68], [69], [70], [71], [72], [73].
Furthermore, it was shown that intense thermal processing is required to observe a significant increase in the β-carotene bio-accessibility.
The time required to observe a self-sustained high-temperature synthesis of NiAl with different combinations of the powders and ball-milling conditions vary by almost an order of magnitude.
Finally, the efficiency of inducing the thermal energy required to observe a bolometric response has been related to the sample's domain size at the core of the antenna structure.
A power calculation using G*Power [36] indicated 36 participants were required to observe a medium effect in the primary outcome, where f = .25, power is.95 and the error of probability is set at.05.
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It is well-known that cells are very sensitive to this lipopeptide mainly due to its effect on the cell membrane, thus low concentrations are required to observe an effect on cell viability.
It had previously been reported that in acute conditions, the dose of a given SSRI required to observe an inhibition of hippocampal pyramidal neurons is at least 5 to 10 times higher than that able to suppress the activity of DRN 5-HT neurons [21].
The MIC of CAPE was 64 µg/mL, well above the 4 µg/mL concentration which was required to observe an increase in C. elegans survival [6], suggesting the compound maybe involved in a role besides inhibition of fungal growth, and thus conferring the observed increase in C. elegans survival.
The higher the within-subject variation, the larger the number of subjects required to observe an effect within a subject and the lower the score.
The higher the between-subject variation, the larger the number of subjects required to observe an effect between groups and the lower the score.
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