For systemic administration, novel delivery systems are required to confer "drug-like" pharmacokinetic and pharmacodynamic properties.
We now examine the minimal hepatic G6Pase-α activity required to confer therapeutic efficacy.
However, the precise interactions required to confer alcohol sensitivity to a particular protein remain undefined.
In our study, M40A and P211L are located outside the MphI macrolide-binding pocket and both mutations are required to confer resistance to C3 cladinose macrolides.
Both the xylA (xylose isomerase) and xylB (xylulokinase) genes from Escherichia coli were required to confer xylose utilization, but a xylose-specific transporter was not required.
Instead the FWC suggested employers be required to confer with employees to "genuinely try to reach agreement" on flexible work and provide a comprehensive explanation of reasons for a decision to refuse it.
A particularly interesting, and perhaps less well known and underappreciated, application of Flp in revealing unique DNA topologies required to confer functional competence to DNA protein machines is discussed.
This may imply a single substrate specificity of P. putida strain S13.1.2 ArsR protein towards arsenic and it is also possible that presence of As III) is required to confer resistance to Sb III).
Evaluation of this series of CSSLs, each possessing one of the pi21 alleles in the genetic background of a susceptible cultivar, clearly demonstrated that all except one were susceptible, and suggested that two deletions in the allele are required to confer resistance (Fukuoka et al. 2009).
A quorum of senior monastics is required to confer full ordination, said Sallie King, professor of philosophy and religion at James Madison University.
Our third subject carried Envs with a W680R substitution causing variable resistance to 4E10, indicating that residues outside the MPER are required to confer the phenotype.
