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In this procedure, all controls are in general required to be activated, i.e. nonzero, at the same time.
The energy consumed in the sleep state is, however, non-negligible, since the small cell is required to be activated back to the on state very quickly [35].
It has also been revealed by Hausenloy et al. that the mKATP/ROS/PKC pathways involved in IPC are required to be activated during early reperfusion in order to achieve the protective effect [ 62].
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To exert their function, Rabs first require to be activated in a reaction requiring guanine nucleotide exchange factors (GEFs).
This is consistent with the idea that the intronic cryptic sites are generally not under selection for adjacent functional regulatory binding sites, and, in order to be activated, are required to be substantially stronger than the natural site.
See online Supporting Information (Text S1) for a discussion of how this finding relates to the question of whether the pMNS requires objects to be activated.
At resting membrane potentials, VGSCs are closed, requiring depolarization to be activated.
Moreover, the Ca2+-binding kinetics of CaM limit its range of action and potentially require CaM to be activated within Ca2+ microdomains (Saucerman and Bers, 2012).
Following alkylation stress, in the absence of MGMT, the repair proteins are required and are to be activated for recombination repair.
NOS2 is expressed in the myocardium [ 50] and in many other organs on demand and requires several hours to be activated (for review see [ 23]).
Unlike many kinases that require a signal to be activated, GSK3 is constitutively partially active; therefore, signals impinging on GSK3 can either decrease or increase its activity.
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