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Required titre of virus transfected vector, drug concentration of precursor and radiation dose were lower than those of single treatment.
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According to the manufacturer of Q fever IFA IgM, the diagnosis of recent C. burnetii infection requires a titre ≥1 16 for both phase I and phase II antigens (package inserts; Focus Diagnostics; 2009, http://www.focusdx.com/focus/packageInsert/IF0200M.pdf).
It will also allow estimates of the minimum antibody titre required to eliminate transmission in a given location.
A change in orientation of the toxin conjugated to the surface could explain the relatively low antibody titres required to produce a response on this NEO chip surface in relation to the titre of this antibody reported in the ELISA study (Bürk et al. 1995).
The minimal bacteriophage titres required for the intended clinical applications are unknown.
Notably, the increasing upstream titres required to satisfy the demands for higher protein yields place considerable economic and physical pressure on these systems.
Thus, whilst the neutralizing antibody titre threshold required for protection against RVFV infection is currently unknown, development of vaccines that elicit antibody titres within the range induced by natural infections is a very attractive way forward.
Thus, the examination of paired serum samples is considered the most reliable serodiagnostic procedure with increasing titres being required to confirm the diagnosis.
In patients 1 and 2, this type of hyperthyroidism rapidly converts to hypothyroidism in the presence of high auto-antibody titre and subsequently required permanent Thyroxine supplement.
A minimum of 2 titres difference was required to take into account the known interobserver variability in direct agglutination test reading (+1/−1 titre).
Moreover, Sikes [ 30] found that the virus titres excreted in fox saliva were lower than the dose required to infect skunks, while the titres generally found in the saliva of experimentally infected skunks were high enough to kill foxes, suggesting a mechanism through which viral genotype effects could influence onward transmission.
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