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TIL-based therapies have only been offered in small phase I/II studies in a few centers given the highly specialized care required, the complexity of TIL production and the very intensive nature of the three-step treatment protocol.
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However, the scheme has the following three disadvantages: (1) It requires the complex computation overhead, (2) it requires the complexity of the public-key management in a PKI, and (3) user's privacy is not kept confidential.
The GFDM modulator and demodulator proposed in [4] require the complexity of the M-point DFT algorithm with additional K times complex multiplications over repeated chunks of M complex samples, resulting from a DFT operation.
GPF requires the complexity of O(L 4 M), and the calculation of the particle weight takes most time in the algorithm.
The computation of S k demands most time in EHIF filtering, and whole algorithm requires the complexity of O(L 4).
The ConstructBurst function requires the complexity of O s), where s is the average number of loops to evaluate each possible height-width pair.
To find a most likely keystream of (10), an exhaustive ML search requires the complexity of ({mathcal {O}}left (2^{N}right)), which would be computationally infeasible if the keystream length N is sufficiently large.
Whereas a phylogenetic tree requires the complexity of all of the pairwise relationships in a multiple sequence alignment to be projected down into one dimension, a sequence similarity network can show multiple neighbors for a given sequence.
However, a BIA model that includes prevalence and incidence often does require the complexity of a cost-effectiveness model, and therefore can be based on an extension of the underlying cost-effectiveness model.
Prevalence-based and incidence-based models are often developed independently from the cost-effectiveness model, because those models usually do not require the complexity of a cost-effectiveness model.
These costs depend on whether the intervention requires legislation, the level at which administration is required, and the complexity of monitoring and evaluation needed.
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