If we required that the interactions be causal (at the risk of circularity), then it is still true that in real cases there are many causal interactions continuously affecting processes.
Moreover, our method requires that the interactions between these modules will account for a large portion of the data.
To call a match we required that the CLASH interaction and the prediction share both (1) the miRNA name (2) the target position in the mRNA.
These factors require that the soil structural interaction must be studied in detail, taking into account the specific effects such as the excavation influence and the building rocking motion due to seismic wave propagation.
First, the in vivo nature of the assay requires that the phosphopeptide protein interaction is specific within the context of a cellular milieu.
As has been noted, the Dobzhansky-Muller model does not require that the epistatic interaction cause absolute loss of hybrid fitness (i.e., lethality or sterility) (Coyne and Orr 2004).
We employ a parity principle of space inversion equivalence by requiring that the catalytic interaction coefficient for a given pair of molecules would be equal to that corresponding to their respective enantiomers, resulting in a chiral 2 N G × 2 N G β matrix.
DOI: http://dx.doi.org/10.7554/eLife.06807.014 A liquid state requires that the molecular interactions are weak and permanently changing (Hyman et al., 2014).
Kawakami et al. [ 35] previously reported that LRRK2 did not promote phosphorylation of tau S199/S202/T205 in vitro and instead increased phosphorylation of T181 in cell culture and in vitro, a modification of tau that required the interaction with microtubules.
Interestingly, soluble APP-Fc not bound to beads was also able to promote AChR clustering, suggesting that focal clustering of APP on opposing beads is not required, but that the interaction of APP, either in a dimeric (APP-Fc) or monomeric (APP-FLAG) form, with the myotube surface is sufficient to induce initial clustering.
