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Acute renal failure developed on the second week of treatment which required termination of amphotericin-B.
In the 5αP-treated group, two mice had palpable tumors by day 20, four by day 23, and all six by day 33; the tumors developed very rapidly, so that by day 46, the tumor volume was 2,431.8 ± 374.4 mm3 (14.8-fold larger than in the controls; P < 0.001), and the tumor burden required termination of this group.
Of the 66 patients who received dexmedetomidine, 16 had transient episodes of hypotension (MAP < 60 or > 30% reduction from pre-infusion BP) and/or bradycardia (HR < 50), mainly during the loading dose, of which three patients required temporary interruption of the infusion and three others required termination of the infusion.
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However, the combination of ipilimumab+BRAF inhibitor vemurafenib produced significant hepatotoxicity, requiring termination of a phase I trial.
Finally, the Boyden chamber is also limited because cell counting requires termination of the experiment; a time course therefore requires multiple devices.
After a further 18 months of Trastuzumab, the patient developed cardiac failure requiring termination of Trastuzumab therapy and eventually died as a consequence of metastatic disease.
There is consensus that neither LTBI following contact of a patient with MDR/XDR-TB nor active MDR/XDR-TB during pregnancy requires termination of pregnancy [ 230].
Although eight subjects did not have a tolerability data recorded, their post procedure pain scores were of a low intensity and did not require termination of the procedure.
According to available studies on ARVC/D patients, the protocol of programmed ventricular stimulation should include a minimum of two drive-cycle lengths and three ventricular extrastimuli while pacing from two RV sites (apex and RV outflow tract); inducibility is defined as the induction of either VF or sustained VT, ie, lasting >30 s or requiring termination because of haemodynamic compromise.
This issue of partial versus total functions (meaning those defined over all inputs) is raised in the appendix of Mossio et al. [ 40] Cárdenas et al.[ 8] in their rebuttal of that paper, state that Rosen's definition of computability requires termination after a finite number of steps, presumably regardless of the input.
Unexpectedly, tumors continued to grow in both animals as shown on MRI (Figure 7A), requiring termination and sacrifice of ZD839 at one week and ZD835 at 4 weeks post doxycycline withdrawal.
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