For designed protein protein interactions (PPIs), required specificity can be notoriously difficult to engineer.
The sceptics claim that detection with immobilized protein binders and sample labelling will not provide the required specificity.
In practice, the preparation of such conjugates is challenging, and sometimes the produced conjugates do not have the required specificity and produce background noise [20].
The findings suggest that the required specificity for effective communication could be obtained through modification of echolocation variants when adaptations for orientation and foraging constrain the evolution of complex communication signatures.
The results showed the required specificity, efficiency of the real-time PCR reaction and comparable selectivity with the previously reported method, therefore their possible complementarity for food and feed analysis is discussed.
Thus, monoclonal antibodies targeting tumor-associated antigens may deliver the required specificity but may lack efficacy.
These residues likely contribute to the required specificity for binding numerous hydrophobic small molecules.
Most small molecules used to date do not have the required specificity.
To select interesting motifs we required specificity score < 1e-10, palindromicity > 0.7, MAP score > 5, and at least 8 sites conserved in 8 genomes.
The structural features of Y-family polymerases could potentially be exploited to achieve the required specificity needed for a polymerase inhibitor.
