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Each of the leadership contenders need to secure the nomination of at least 35 Labour MPs and although Mr Corbyn is trailing on just 11 nominations, he is confident of securing the required number needed to enter the one-member, one vote election.
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The number of patients required for the number needed to treat (NNT) to be within ± 0.5 of the true value varies with the efficacy of an analgesic [ 11].
Generally, the larger the required number of events, the larger or longer the trial needs to be.
Overall, with 79.9% of the required information size, the number needed to treat was 38 patients (95% confidence interval: the number needed to treat is >18, and the number needed to harm is >251) for the comparison of albumin with crystalloid fluid.
Overall, with 80.5% of the required information size, the number needed to treat was 37 patients (95% confidence interval: number needed to treat is >18 and the number needed to harm is >297) for the comparison of albumin with control fluid excluding trials at high risk of bias.
Overall, with 85.6% of the required information size, the number needed to treat was 37 patients (95% confidence interval: the number needed to treat is >18, and the number needed to harm is >517) for the comparison of albumin with control fluid.
Overall, with 78.9% of the required information size, the number needed to treat was 37 patients (95% confidence interval: the number needed to treat is >18, and the number needed to harm is to >297) for the comparison of albumin with crystalloid fluid, after excluding trials at high risk of bias.
Overall, with 5.8% of the required information size, the number needed to harm was 172 patients (95% confidence interval: the number needed to harm is >9, and the number needed to treat is >10) for the comparison of albumin with colloid fluid.
Overall with only 2.2% of the required information size, the number needed to treat was 10 patients (95% confidence interval: the number needed to treat is >4 and the number needed to harm is >19) for the comparison of albumin with colloid fluid, excluding studies at high risk of bias.
Nevertheless, the rate of jaundice requiring phototherapy was lower in babies whose mothers had received corticosteroids (34 (24%) v 49 (38%); P=0.01), resulting in a 47% lower risk of requiring phototherapy and a number needed to treat of 7 (4 to 33).
These differences can also be transformed into a number needed to treat required to achieve an MID in one patient after a given time period.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com