To do so, we prepared required meta-data including TR value, field strength, gender, and handedness of each subject and experiment.
Some of these findings have not been reflected within this review as, to do so, would have required meta-analysis of the literature.
If we would have the required meta-knowledge, answering the questions truthfully would be a good guide for determining empathy as defined within the context of each scale.
6, 7, 19 Due to heterogeneity across included trial populations, treatments and methods, the required meta-analysis information size additionally need adjustment for variation across trials.
First, we check if the required meta-annotation entries are directly available in GEO, GEO2R or ArrayExpress (http://www.ncbi.nlm.nih.gov/geo/geo2r/).nih.gov/geo/geo2r/
34 To minimise random error, we calculated an information size (that is, required meta-analysis sample size) as large as that of an adequately powered trial and applied trial sequential analysis to the meta-analysis.
We calculated the required meta-analysis information size assuming a type I error of 5%and90%0% power, a baseline event rate of 40% and a relative risk reduction of 15%.
8, 10, 11 We determined the required meta-analysis information size for detecting a 25% relative risk reduction in TB, assuming a control group incidence rate of 5% (approximately the median rate across trials) and assuming that 20% of the total variation in the meta-analysis would be explained by variation across trials (heterogeneity).
21, 22, 46 In meta-analysis, the monitoring boundaries may be applied analogously every time one or more trials are added up till the point where the number of patients in the meta-analysis surpasses the required meta-analysis information size.
