Customizable: It should be a generic solution for different applications and be extensible to meet the requirements of more complex pipelines without requiring major changes in the underlying architecture or design.
Effective reform requires major changes in patient behavior.
That would require major changes in the American economy.
Halting this progressive alienation will require major changes in outlook and policy on both sides of the Atlantic.
Greater fairness in taxation would require major changes in the tax structure, like allowing most taxpayers to obtain deductions currently tied only to the income tax.
The only answer, Mr. Pally said, is to allow construction of many more studio and one-bedroom apartments, town houses and condominiums across the Island, which would require major changes in zoning laws -- and political attitudes -- in most towns.
The natural sciences are critical in identifying these problems and seeking potential solutions, but resolving these problems will require major changes in the social systems within which our energy systems and food systems are embedded.
Promoting manufacturing will require major changes in tax and trade policies that currently foster offshoring, including implementing provisions to punish currency manipulation by countries like China and help American producers harmed by discriminatory foreign value-added tax systems.
It has been an especially bad year for Albany, as a convergence of institutional gridlock, a politically volatile court order requiring major changes in education spending and a series of scandals have left lawmakers' morality, as well as their professionalism, being questioned.
Neither Mr. Bush nor Mr. Kerry wants that to happen, but preventing it is expected to cost a least $500 billion over 10 years and would probably require major changes in the rest of the tax code to avoid further widening the budget deficit.
