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The other 111 modules required major changes.
This adaptation required major changes in both the structure and the biochemistry of leaves, dwarfing anything biotechnology has yet attempted.
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Customizable: It should be a generic solution for different applications and be extensible to meet the requirements of more complex pipelines without requiring major changes in the underlying architecture or design.
Effective reform requires major changes in patient behavior.
That would require major changes in the American economy.
Halting this progressive alienation will require major changes in outlook and policy on both sides of the Atlantic.
A healthier, if sometimes adversarial, relationship also requires major changes by business leaders, starting with the Business Roundtable.
The latest change to N.C.A.A. testing will apply even tougher standards, Russell said, requiring major changes to college bats by the 2011 season.
However, most charities and campaigning groups are not set up to account for spending on a constituency basis, and this would require major changes on accounting processes.
Greater fairness in taxation would require major changes in the tax structure, like allowing most taxpayers to obtain deductions currently tied only to the income tax.
The only answer, Mr. Pally said, is to allow construction of many more studio and one-bedroom apartments, town houses and condominiums across the Island, which would require major changes in zoning laws -- and political attitudes -- in most towns.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com