Single applications may not provide all required information, requiring use of combinations of applications [ 40].
The problem of minimizing the amount of experimentation required to obtain the required information is itself a very large subtopic of statistical experimental design.
Suppliers who noticed that the inquirers were members of universities are legally required to provide the required information at the time of supply of an article according to Art. 33(1), which relates to information transfer for articles intended for professional use.
The broker fills in the required information under "Investment Objective".
(4) Calculate required information sizes (≈ the a priori required number of participants for a meta-analysis to be conclusive) for all outcomes and analyse each outcome with trial sequential analysis.
A similar methodology should apply to a meta-analysis that does not reach a required information size (≈ the a priori required number of participants for a meta-analysis to be conclusive) [ 25, 26].
Only 27 958 (44%) of the heterogeneity adjusted required information size of 63 446 patients required to detect a 10% relative risk reduction for non-fatal myocardial infarction were accrued (fig 7).
Lastly, the assessor, based on his toxicological knowledge, commented on whether the study was necessary to obtain the required information, recognizing that such an evaluation required value judgments.
The required information is naturally specific.
The required information size was 4894.
