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Also, (as elaborated in our responses to the first reviewer), it appears likely that an A (or G) is required in position 37 in order to stabilize the anticodon-codon interaction by base stacking on the anticodon-codon helix [ 17].
As suggested above, a small residue is proposed to be required in position 369 to allow efficient gate closing, while larger residues would collide with the amphiphilic S4 S5 linker helix.
Previous studies have shown that a heterocycle (either proline or thiazol in e/oxazol in e) is required in position 1 in order for macrocyclase enzyme to be functional.
Similar(57)
A summary of the SAR is given in Figure 5. Small alkyl groups were required in positions R (methyl) and R (methyl and ethyl) as replacement of R or both R and R with hydrogen led to a loss in activity (42 and 43).
Required accuracy in angular position around X-axis is more than that required in angular position around Z-axis.
These can be standard CRB checks or enhanced CRB checks, depending upon the degree of involvement required in the position.
Different skills and strengths are required in each position in the line-up, so ensuring that Hoy and Kenny - two of the world's finest sprinters - ride to their full potential.
Reinforcements will be required in some positions, but Adkins is relishing the challenge.
CT scans were performed with Philips Medical Systems (Cleveland, USA) to demonstrate where and how far the previously positioned needles needed to be inserted and whether more needles were required in a supine position.
Tie all the bars required in their correct positions.
To position TSIs, both the logical positioning and physical positioning are required in the security architecture.
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