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Repeat dose experiments are required in long-term model systems to estimate the degree of circuit saturation with time.
A patient might require long term care due to a sudden illness or injury where rehabilitative therapy is required in a long term facility such as a nursing home.
Reinforcements would help but arguably they are not required in the long term.
Most of the barriers identified are intrinsic to the private facilities and may require focused individual-level efforts; however at the same time external facilitators from the administration and clear legal frameworks will be required in the long term.
Collaboration with Mexico on prevention strategies, from education to regulation of the production of unpasteurized dairy products, and elimination of M. bovis from dairy cattle will be required in the long term to ensure that this mode of transmission is eliminated.
Previously we reported that the MSDGC-1 which possesses both DGC and PDE-A activities is required for long term survival in M. smegmatis, under nutritional starvation.
Transplant procedures may be required for long term survival in a small proportion of surgical NEC survivors with failure of intestinal function [ 38].
Indeed, retinoids are required for long term synaptic plasticity in the hippocampal formation (HF) [14], [15], a key structure in memory processing [16], [17].
While the present decline in birth rates in Europe requires changes in long-term planning for an aging population, it also has benefits for society at large and is mitigated by migration and anticipated increase in child-bearing among young people just entering adulthood.
The tolerability of drugs for the treatment of osteoporosis requires evaluation in long-term studies and the collection of postmarketing data.
The follow-up of drug addicts over years usually requires patients in long-term contact with the support system.
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