Sentence examples for required for the checkpoint from inspiring English sources

We conclude that Mrc1 is not required for the checkpoint response to cdc13-1 dependentelomerere uncapping.

Furthermore, the results provide an initial indication that Aurora B activity is required for the checkpoint response in the absence of microtubules.

The function of the FHA domain is largely unknown but is required for the checkpoint function and might be involved in the binding to phosphorylated proteins [ 19].

We also examined if the different mec1 alleles interacted with Lcd1/ Ddc2 (ATRIP in mammalian cells), an association required for the checkpoint functions of Mec1 (Rouse and Jackson 2000; Paciotti et al. 2000; Wakayama et al. 2001).

In addition, we have previously shown that Aurora-dependent phosphorylation of budding yeast Mad3p is required for the checkpoint response to lack of tension at microtubule-bound kinetochores [6].

Also, SMC1, as a subunit of cohesion, is not only activates DNA repair but also facilitates the recruitment of checkpoint proteins, which activates the intra-S and G2/M checkpoints, indicating that the activation of SMC1 after DNA damage stresses is required for the G2/M checkpoint, as well for intra-S checkpoint.

This result suggests that bub-1 function is specifically required for the spindle checkpoint in the M phase, which is missing from the endoreduplication in the C. elegans intestinal cells.

However, whether this protein is part of a kinetochore subcomplex or acts as a monomer, how it is recruited to centromeres, whether it binds to MTs, contributes to spindle integrity or is required for the spindle checkpoint response in budding yeast is unknown.

In contrast, cds1Δ cells showed mild elongation phenotype similar to wild-type (non-treated: 12.13 µm; CPT-treated: 14.84 µm; p-value = 0.0006), indicating that Cds1, a master kinase required for the replication checkpoint, does not have a major role in CPT-dependent cell cycle delay.

In addition, p53 is required for the G2/M checkpoint and apoptosis in hESCs after DNA damage [ 40, 41].

An additional distinct set of signaling elements, including CD40 ligand (CD40L) and MHC class II, also appears to be required for the peripheral checkpoint.