Sentence examples for required for sensitizing from inspiring English sources

The authors demonstrated using inside-out patches of HEK-293 cells expressing TRPA1 that short polyphosphates (2 65 residues) are required for sensitizing this channel to pungent chemicals and for preserving the protein in the functional conformation.

The development of insulin resistance in mammals with elevated expression of an antioxidant enzyme and suggest that increased GPx-1 activity may interfere with insulin function by overquenching intracellular reactive oxygen species required for insulin sensitizing [ 22].

It is perhaps surprising that cysteine residues in both the SD and IBC are required for thimerosal to sensitize IP3R1.

However, further experimentation showed that this was not the case since a reduction in autophagy in both cell types using shRNA to genes required for autophagosome formation actually sensitized to CQ-toxicity.

In particular, mutations affecting the function of the heterohexameric GIM (Genes Involved in Microtuble biogenesis)/prefoldin protein complex, which is required for formation of functional tubulin, sensitized cells to As.

We determined in our experiments that cyclin E was required for cells lacking FBW7 to be sensitized to SAC knockdown.

This compensatory growth is in part an acceleration of developmental growth and thus sensitizes cells to reduced levels of factors required for more rapid growth.

Healthy AT is also required for proper secretion and the physiological balance of adipokines like adopinectin and leptin, which sensitize cells to insulin.

We have also found that active SCD1 may be required for neoplastic cells to survive a lipotoxic stress since SCD1 knockdown increases basal apoptosis and sensitizes the cells to the cytotoxic effects of excess SFA [19].

Notably, IGF-IR inhibition had limited effect on estrogen-dependent proliferation in the cell lines, but was clearly required for survival, suggesting that the combination of letrozole and IGF-IR inhibition sensitizes cells to apoptosis.

Since efficient repair of IR-induced DSBs is required for the clonogenic survival of irradiated cells [8], [9], we hypothesized that suppression of DSB repair via inhibition of IKKβ kinase activity can sensitize tumor cells to IR.