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When the key elements (O2, Fe2+, and 26S proteasome) required for PHD activity to hydroxylate HIF-1α and for the subsequent VHL-mediated ubiquitination and degradation are missing or inhibited, or when the ODD of HIF-1α, which is the targeted domain by the VHL ubiquitin ligase complex, is absent, 1, 9 PA loses its ability to downregulate HIF-1α.
These data demonstrate that RIM is not required for PHD and further separate the mechanisms that promote PHD vs PHP.
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Milliequivalents of acid required for pH adjustment were determined by weighing the titration containers.
Soil predictions were required for pH, EC, clay percentage, stone content, drainage, and depth to sodic and impeding layer.
Urea as an alternative N source was easily assimilated by the studied yeast and avoided strong acidification (much less base was required for pH control).
In C. albicans, calcineurin appears to be required for pH homeostasis (Kullas et al. 2007).
Larger blood volumes and longer test times were required for pH estimation.
The Na+/H+ exchanger NHE1 is a highly regulated membrane protein that is required for pH homoeostasis in cardiomyocytes.
The D loop, involved in gating of land plant PIPs, has a conserved loop length and the histidine required for pH gating [ 20] is also present.
The physiological role of CA VI has not been established although it has been suggested that it is required for pH homeostasis of the mouth [ 56].
The C. glabrata GPI-anchored aspartyl protease Yps1 has been demonstrated to be required for pH homeostasis (Bairwa and Kaur 2011) and virulence in a murine systemic infection model (Kaur et al. 2007).
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