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These findings led us to propose that the reductions in cell size and amount of protein provide energy required for functions that are augmented during cellular transformation, such as cell replication.
GRP94 is highly conserved in vertebrates but not in yeast and has been well documented to be inducible by a variety of metabolic stresses, suggesting that it is uniquely required for functions in vertebrates not shared by yeast.
Thus, COPI mutations could affect secretion in two ways: on the one hand, by slowing down the movement of cargo through the Golgi and on the other by blocking COPII-mediated transport due to the lack of recycling of proteins back to the ER, which are required for functions within the ER.
Next, we tested if the HSC70cb is required for functions of other HSP40 family proteins.
Importantly, this septin complex is required for functions that are necessary for the later stages of cell division.
About half of the expressed transcripts were in common between two tissues types, presumably required for functions shared between these cell types.
Similar(52)
This repeat is preceded by a conserved A/T rich sequence that is required for function.
Text boxes in the figures show actions and actors required for functioning networks and arrows illustrate linkages between them.
ATP hydrolysis by Rvb1/2 is required for function; however, the mechanism that drives substrate remodeling is unknown.
But the mixtures tend to flow away or collapse before they can stiffen into the elaborate shapes required for functioning organs. .
If the C-terminus of a protein is required for function then this will not be an appropriate method.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com