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Extensive follow up and supportive treatment is often required for delayed neurological damage.
This finding is in direct contrast to situations with many other GPCRs, where β-arrestins are required for delayed ERK phosphorylation [31].
To examine if p27 is required for delayed proliferation in Lck-Bcl-2 transgenic mice, purified splenic T cells from Lck-Bcl-2 p27−/− and control mice were activated with immobilized anti-CD3 antibody.
We have shown that transcription and translation were required for delayed p65 activation and subsequent NF- κB-dependent death.
RL neurons, however, are required for temporal delay and coupling between multiple respiratory oscillators.
Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice.
[Editors' note: what now follows is the decision letter after the authors submitted for further consideration.] Thank you for sending your work entitled " Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators" for consideration at eLife.
Based on these results, we tested whether ULK3 was required for abscission delays induced by the abscission checkpoint.
Budding yeast and mammalian studies suggest that Aurora B is only required for checkpoint delays where kinetochores lack tension as a result of inappropriate attachments [7 9].
The DNA replication checkpoint was implicated in this scaling phenotype, as an intact checkpoint was shown to be required for the delayed activation of late origins in response to hydroxyurea treatment.
However, a delay budget of up to 250 ms is still acceptable if 100 ms extra delay required for packet processing and propagation delay in the congestion core network is considered.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com