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We compared these results with a scenario that minimizes the total number of ecoregions required for conserving all species, irrespective of other factors.
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The overarching hypothesis is that residues required for conserved tropomyosin functions are conserved.
Following the linker segment is a hydrogen-bonding moiety that is required for making conserved hydrogen bonds with the C-Helix and DFG motif.
The core proteins required for fusion are conserved from the yeast vacuole to the synaptic active zone (Table 1).
Their downstream elements histidine phosphotransfer proteins (AHPs) carry conserved amino acids required for phosphotransfer via a conserved histidine residue.
Moreover, the DISC1 arginine-rich motif required for TRAK1 binding is conserved in mouse, apart from a conservative substitution of glutamine for the first arginine (27).
Generally speaking, viral proteins required for replication are highly conserved within viral species and genera, and occasionally this conservation may extend across an entire family of viruses.
Our findings provide an explanation for why auxiliary structures not required for oscillation are evolutionarily conserved and suggest simple ways to evolve or design robust oscillators.
A recent study found that numerous host factors required for DENV replication are conserved between invertebrate and vertebrate hosts [35].
This is consistent with the observation that components of the COP9 signalosome, which is required for COP1 localization, are conserved in mammals [ 43].
The mechanism through which MccF mediates resistance against microcin C7 is uncertain; however, MccF belongs to the peptidase S66 family, and all the residues required for LdcA activity are conserved in it [ 36].
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