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Although the structure of a full-length DRF would be required for clarification of the presented models, our work here provides the first structural insights into the mechanism of the DRF autoinhibition.
Further studies are thus required for clarification of the exact pathogenic mechanism of LPG.
CEACAM3 may inhibit cell proliferation/invasion of LADCA cells as a binding protein, but further investigations are required for clarification.
Clearly, more studies will be required for clarification of the functional differences between TS1 and TS4 (Fig. 7).
This is consistent with the suggestion that androgens may act, at least partially, through the upregulation of 17βHSD2 and thus modify the balance of estrogen production in ILC tissues, although further investigations are required for clarification.
Further study is required for clarification the role of genetic variation around these SNPs in expression pattern of the CTXN3 and SLC12A2 genes, which may be involved in schizophrenia pathogenesis.
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However, as the Rab10 mutation in mice was difficult to study due to the severity of the phenotype, conditional knockout strategy is required for further clarification of Rab10's function.
Therefore, more sophisticated models containing not only inhibitory molecules but also the complex involvement of multiple kinases are required for further clarification of the regulatory mechanisms underlying the increase in the phosphorylation rate on a network-wide scale.
US-guided interventions are required for further clarification in mammography occult findings and preoperative wire marking.
More extensive functional analysis on the DNMT3A protein should be required for the clarification of this finding.
Further studies with more strains of each of the species within these complexes are required for the clarification of taxonomic ambiguities.
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