Sentence examples for required for activating from inspiring English sources

Alternatively, the SCRD may hold a vital interaction site for another component essential for this process or possess a key site of posttranscriptional modification required for activating this activity.

Moreover, the overexpression of either wild-type PKD3 or the constitutive active form of PKD3 (PKD3 CA) enhanced the expression of NF- κB-Luc, whereas the kinase-dead mutant (PKD3-KD) did not), indicating that the kinase activity of PKD3 is required for activating NF- κB signaling pathway.

We speculate that the activity of Fyn kinase is required for activating cancer cell growth on rigid fibronectin matrices.

The release of such inhibitors is required for activating procaspases.

Employing p53 K3R knocknock-inse, Li and colleagues demonstrate that acetylation of mouse p53 at K117/161/162 (corresponding to human K120/164) is required for activating p53-dependent transcription but dispensable for p53 stabilization (Li et al., 2012).

Interestingly, ect4 (CG34373) and the serine proteases SPE (Spatzle-Processing Enzyme, CG16705) and spheroide (CG9675), required for activating Toll but upstream of spz expression [71], [72], were upregulated.

Importantly, we found that dynamin-mediated endocytosis was required for selectively activating Jagged-1-mediated Notch3 signaling.

All the above data demonstrate that Wg signaling is required for ectopically activated Bsk-induced cell death, however, it remains unknown whether Wg pathway also contributes to the physiological function of Bsk signaling.

Interesting work by Vuori and colleagues showed that pY221 Crk was required for recruiting activated Rac1 to the membrane fraction, and Rac1 re-localization was prevented by expression of the Y221F Crk mutant [ 172].

It seems a likely possibility it does, since USP22 is required for MYC activated transcription [ 52], but whether ubH2B directly blocks recruitment of a kinase (P-TEFb) responsible for serine 2 phosphorylation in CTD of Pol II is not known [ 53].

The reason why FACs require wounding for activating systemic JA accumulation remains unknown, but it is possible that wounds are necessary for efficient loading of FACs to mechanically broken vascular tissues.