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However, efficient clearance from the body to avoid side effects may result in the reduction in residence time required for accumulation in target tissues.
Two motifs within the independently stable H/ACA domain of hTR are required for accumulation of the mature RNA in vivo.
However, when optimising nanoparticles for targeted therapy their size is only one parameter that needs to be considered together with the ease of surface functionalisation, the time required for accumulation in tumour tissue, and the interaction with tumour cells.
Thus, Syk-Tyr323 is specifically required for accumulation of PI3K p110δ but dispensable for the enrichment of Cbl at the leading edge.
The LRP5Δ receptor responded strongly to WNT3 ligand and was shown to be required for accumulation of nonphosphorylated transcriptionally active β-catenin, MYC expression, parathyroid cell growth in vitro, and parathyroid tumor growth in vivo in SCID mice.
Ankyrin-G is required for accumulation of voltage-gated sodium channels in excitable membranes at axon initial segments of neurons [7], [8] and at transverse-tubules in cardiomyocytes [9].
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The accumulation of decanoic acid occurred in a shorter time compared to that required for the accumulation of 10-hydroxydecanoic acid.
Additionally, it is known that ABA is required for proline accumulation during a stress response, however, ABI is a negative regulator for proline accumulation in Arabidopsis [ 30].
The finding that SET8 is required for 53BP1 accumulation during DDR, however, raises a question regarding how 53BP1 might accumulate during all the stages of the cell cycle.
These results suggest that the two GTP-binding proteins are required for the accumulation of OsMAPK6 protein and, possibly, for its activation as well.
High-productivity methods are required for the accumulation of long-lived isomers in amounts that are sufficient for the creation of experimental targets.
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CEO of Professional Science Editing for Scientists @ prosciediting.com