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The diagnosis of a variant form of LND required evidence for an HPRT gene mutation or reduced HPRT enzyme activity in a male patient without the self-injurious behaviour typical of classic cases.
A systematic study of such hazard scenarios would provide the required evidence for properly answering the aforementioned questions.
Therefore, testing the wire's surface after such an experiment for evidence of agglomeration on the wire's surface may not necessarily produce the required evidence for the latter.
Scientifically, the key question is how to select the most promising ingredients and demonstrate the required evidence for their effect (Blundell, 2010).
The result will contribute to the required evidence for generating future investments in RTI prevention and document non-fatal outcomes in LMICs settings in order to inform investment prioritisation.
The spectrum of factors preceding the onset and progression of the metabolic syndrome is too wide to stratify in traditional clinical and epidemiological trials [S22,S23], leading to associations without the required evidence for causation [S24,S25].
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(i) Compared to RANS, which require evidence for their predictions, the LUM has the significant advantage that the quality of predictions is relatively independent of the RANS model applied.
Initial target validation requires evidence for modulation by selective probes.
Instead, we require evidence for mitochondrial recombination at a population level.
This would, at the very minimum, require evidence for on-going CO2 fixation and the perpetuation of body mass during starvation.
1 The evaluation of new disease-modifying osteoarthritis drugs (DMOADs) is performed on the same basis, since the regulatory bodies currently require evidence for an impact on radiographic joint space narrowing (JSN) and an impact on symptoms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com