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We suggest that the overrepresentation of serine endopeptidases may be due to the required breakdown of many meiotic proteins following their utilization in meiosis in order to prevent erroneous aggregation of many self-assembling protein complexes that may interact with DNA.
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Thus, this suggested chain of processes requires breakdown of the condition of the frozen-in field line during the expansion phase.
The growth of new blood vessels also requires breakdown of the surrounding extracellular matrix (ECM).
Shh-stimulated proliferation of astrocytes may require breakdown of the blood brain barrier (Sirko et al., 2013).
These data are consistent with the results of several studies showing that neutrophils are a primary source of MMP-9 in diseases requiring breakdown of tissue, such as coronary heart disease (57) or stroke (58), although their potential to contribute significantly to MMP-9 levels in the inflamed joint has not previously been described.
Dietary silicon is mainly in the form of soluble silica [Si(OH 4] or amorphous polymeric silica (phytolithic silica), and the latter, from the cereal (plant) component of the diet, requires breakdown in the gastrointestinal tract prior to absorption as Si(OH 4, a soluble and neutrally charged specie [3,61].
This parameter range is suitable for applications requiring breakdown voltages of 1200 V to 5 kV with a proper edge termination strategy.
MMP and TIMP expression is altered in both benign and malignant tumors, as well as in invasion and metastasis which require breakdown and removal of the extracellular matrix [ 13, 14].
Our results clearly show that Notch2 function in somatic granulosa cells is required for breakdown of germ-cell nests and formation of primordial follicles.
These data indicate that Notch2 gene function in pre-granulosa cells is required for breakdown of the primordial germ-cell nests and assembly of primordial follicles.
The presence of multi-oocyte follicles in Amhr2-Cre/+ Notch2 flox/- mice suggests that Notch2-mediated signaling may be required for breakdown of the primordial germ-cell nests.
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