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Previous studies have identified the amount and the location of the protection provided by current commercially available products but, until now, no evidence has been reported to determine what protection is required based on an understanding of the likely impact and the anatomy of the athlete.

A subsequent review by Bennell and Hinman [ 30] stated that the optimal exercise dosage is yet to be determined and an individualised approach to exercise prescription is required based on an assessment of impairments, patient preference, co-morbidities and accessibility.

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Instead a new approach is required based on a supra-national view of the interconnectedness of the world economy.

Further investigations of seismic tomography with higher spatial resolutions are required, based on a dense OBS network covering a broader area that includes the two strong asperity patches.

Thus, a total of 116 patients (58 per arm) were required based on a two-sided α of 5% (overall power=80%).

In order to determine an appropriate number of replicates to perform initially, we have estimated the sample sizes required based on a range of potential variance.

Thirty-five participants will be required based on a calculation of a 95% confidence interval of 0.65 – 0.95 for the predicted relationship of VO2peak between the 6MWT and the incremental cycle test to achieve a power of 0.80.

Concluding that this peptide is not required based on a line that is not shown to reduce NPF immunoreactivity is not a very strong argument without the appropriate control experiment.

To detect a 5-point change on the most variable individual SF-36 domain score (role-physical), with 80% power and 0.05 tolerance of type 1 error, 293 evaluable patients were required, based on a two-sided paired t test, assuming within-subject test-retest correlation of 0.60 and standard deviation (SD) of 34 (data for the US normal subjects).

Thirty participants per group are also required based on a 0 10 VAS scale (e.g. for dizziness), with a standard deviation of 2.4 and a clinically significant difference of 2 units with a power of 80% and a 5% confidence level.

In order to demonstrate a medium-sized effect (Cohen's d = 0.40), 100 participants in each condition are required, based on a statistical power (1-beta) of 0.80, a two-sided test and an alpha of 0.05 (power calculation with G-power).

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