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Mei-P26 is required at low levels in GSCs and plays a role in self-renewal through repressing translation of Brat as part of a Pum-Nos-Mei-P26 complex (Li et al., 2012).
Functional analysis of these 33 leaderless genes showed that 6 encoded transcriptional regulators (including a TetR homologue), expected to be expressed at relatively low levels, 7 encoded membrane proteins which are also often required at low levels, and 4 were related to pathogenicity functions (additional file 2: Table S2).
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Expression of CDKB2 2 was lower than the CDKB2 1 in endoreduplicated cells indicating that cells were already arranged in root but, due to increase in cell size because of endoreduplication process, its function is required at low level to arrange them [ 36].
However, allowing refrigerant to leave the evaporator without completely vaporizing risks catastrophic damage to the compressor, so superior control is required at low superheat levels.
The essentiality, however, is sometimes difficult to estimate because selenium is required at such low levels for most organisms that it is experimentally challenging to generate strong phenotypes of deficiency [ 13].
As illustrated in Figure 1A, a major consequence of intra-tumoral hypoxia is the metabolic switch from 'normal' oxidative phosphorylation to increased anaerobic glycolysis, which is required for tumour proliferation at low levels of oxygen and nutrients (Vasseur et al, 2010).
This may indicate that Eed1-dependent up-regulation of UME6 is required to keep NRG1 expression at low levels in order to prevent Nrg1-mediated reversion of hyphae to yeast cells.
"The stabilization of greenhouse gas concentrations at low levels requires a fundamental transformation of the energy supply system," the summary of the report says.
These data strongly suggest that increased throughput is required for detection of pathogens present at low levels.
Third, the metabolic pathways activated during sperm capacitation may serve other purposes, such as the synthesis of ROS which, at low levels, are required to promote capacitation.
In skeletal muscle, reactive oxygen species (ROS) and nitrogen species are physiologically synthesized at low levels and are required for normal force production [ 110].
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CEO of Professional Science Editing for Scientists @ prosciediting.com