Thus, the evidence indicates that HIF activation is required and sufficient for maintenance of resistance against lidocaine toxicity.
Here we report that EGFR/RAS/MAPK signalling is required and sufficient to drive damage-induced EB/EC growth.
The experimental results indicated the HIF-1 activation is required and sufficient to reprogram the oxygen metabolism in a mitochondria-dependent manner in RCC4 cells.
Loss- and gain-of-function approaches demonstrate that Nkx2-1 is required and sufficient for Selenbp1 expression in lung adenocarcinoma cells.
This study illustrates the importance of defining and understanding CaP-activated signalling pathways that are required and sufficient for in vivo bone formation.
Here we show that a minimal N-terminal domain of the cavins, termed HR1, is required and sufficient for their homo- and hetero-oligomerization.
Here we demonstrate that Akt-dependent activation of mTORC1 and inhibition of Foxo1 are required and sufficient for de novo lipogenesis, suggesting that hepatic insulin signaling is likely to be intact in insulin-resistant states.
The results indicated that the C-terminal coiled coil region (aa 891 1160) of CENP J is required and sufficient for mSYCP2 NTR binding (Fig. 2A).
In that case, annealing was required (and sufficient) to form the ε-Ti2N phase, stable at 500 °C in the mentioned nitrogen concentration range.
Previous studies have shown that the approximately 70-amino acid tandem zinc finger domain of TTP is required and sufficient for RNA binding, and that the integrity of both zinc fingers is also required.
Performing segregation experiments using cell types with altered myosin activity they have demonstrated that differential actomyosin-dependent cell-cortex tension is required and sufficient to direct the segregation of cell types and determine the final configuration of the segregated domains.
