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This multi-pronged intervention required a substantial time and financial commitment to enact.
Our protocol required a substantial time investment by patients, as they were required to arrive in clinic one hour prior to their scheduled appointment.
While the trial showed that it was possible to prevent menopausal weight gain and to limit the typical post-menopausal rise in low density lipoprotein (LDL) cholesterol, the researchers acknowledged that the 15-session intervention held over 20 weeks was labour intensive and required a substantial time commitment from participants [ 20].
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However, high-level theoretical calculations are very intensive computationally and require a substantial time investment, limiting their application to small/medium size molecules.
Successful completion of the nurse anesthesia program (83 course credits) requires a substantial time commitment averaging 50-60 hours per week (includes class time, clinical, and study time) during the 36-month program.
Successful completion of the Doctor of Nursing Practice Nurse Anesthesia Program (80 course credits) requires a substantial time commitment averaging 60-70 hours per week (includes class time, clinical, and study time) during the 36-month program.
Lasting lifestyle change requires a substantial time investment.
This is probably because of the cytostatic nature of lycopene that requires a substantial time for the alterations of mRNA or protein to exhibit the ultimate cellular death.
Previous studies had to face the major problem of locating each address and verifying it in the field, which requires a substantial time investment (4 ).
However, we accepted the limitation of including only nine physicians performing three cases rated by two raters, as the task of rating 27 TTE scans requires a substantial time demand for a working clinician.
As noted in the methods, being a Sahwira peer educator did require a substantial time commitment in training, refresher courses, and facilitating activities and the voluntary nature of the program may have precluded sufficient exposure to the intervention.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com