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None of the internal fixated fractures required a second reduction.
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Seven patients required dose reductions, of whom two required a second dose reduction.
Twelve patients required dose reductions of 5-FU, three of whom required a second dose reduction, mainly for reasons of stomatitis and palmar-plantar syndrome.
Only three patients (7.1%) required a second dose reduction to 50% of starting dose of 5-fluorouracil and/or of oxaliplatin.
Treatment was definitively interrupted in patients whose AE did not resolve after 2 weeks of discontinuation or who required a second dose reduction.
No patient required a second bendamustine dose reduction.
The primary outcome measure was the number of patients who required a second procedure of fracture reduction after initial treatment.
At least one required a second transplant.
In cases of grade 4 nonhematological toxicity or continued toxicity requiring a second dose reduction, the protocol treatment was terminated.
Among the three DLTs, repetitive grade 4 neutropenia requiring a second dose reduction of pemetrexed automatically meant the termination of the study protocol.
Clear Skies would require a two-thirds reduction in most power plant emissions by 2018, and seek to achieve that goal largely by creating a system in which companies can trade emissions credits.
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CEO of Professional Science Editing for Scientists @ prosciediting.com