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Hence, definitive structure elucidation of such metabolites would have to be based on isolated compounds and required a formidable analytical effort.
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Creating effective machine translation software requires a formidable effort.
Any performance of "Alceste" requires a formidable soprano in the demanding title role.
The low-hanging fruit was plucked long ago, Dr. Weinberg said, and experiments that could advance the ball today require a formidable combination of money, organization and political will.
Unlike most of their precursors, they also require a formidable playing technique.
An oxygen-deprived brain takes about seven minutes to die, which by my calculations would require a formidable 605 farts if the victim continued breathing until brain death, which is unlikely.
These second and third strategies are not readily feasible and require a formidable amount of cooperation across disciplines, large-scale resources and skills which are not commonplace.
Once serious injuries occur, being classified as disabled at Honda requires navigating a formidable phalanx of interlocking insurance and diagnostic companies, not to mention Honda itself, some workers contend.
For the military effort in Afghanistan to succeed, the Pakistani military would have to establish control of much of that lawless territory: a formidable task that would require a new emphasis on counterinsurgency by the Pakistani military and a greater willingness on the part of Pakistani leaders, who may be distracted by the flare-up of tensions with India after the attacks in Mumbai last week.
Using his voice as the sole anchor in an hour-and-a-half set required formidable stamina.
The bureaucracy required is formidable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com