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While this change is not a gene rearrangement, the condition in this sequence required a duplication of at least seven residues.
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Doing so required a constant duplication of effort as they had to repeat the same process for all three prototypes.
We consider the first model less likely since it requires a rare duplication event, which is not known to be promoted by long repeats, to occur three times in different lineages.
Managing craniofacial duplication requires a detailed preoperative evaluation as well as a comprehensive, staged treatment plan.
The tissue-specific nature of their expression coupled with their widespread duplication requires a mitotically-stable global silencing mechanism in all cell types.
Yet, we showed that the exponential dynamics of PPI network evolution under genome duplication requires an asymmetric divergence of protein duplicates.
Our phylogenetic analysis has shown that the human β-globin gene cluster is a fast evolving region by tandem duplication, thus requiring a higher recognition specificity to differentiate the cleavage activities between HBB and its homologous genes.
This suggests that a Bonferroni correction for multiple testing of recurrent CNVs (those flanked by segmental duplications) might require a P-value of <4.1×10 4 to be accepted as a significant association for this type of CNV (P = 0.05/120).
CPAP, a protein required for centriole duplication [30], has also been reported to contain a microtubule-binding domain, but as observed with TBCD, it does not bind microtubules [31].
Supplementary Theorem S17 implies that, for this example, inserting the one required genome duplication at any other copy number configuration would result in a path with more edges.
Furthermore, this model does neither invoke events of horizontal gene transfer nor massive secondary losses, although it requires an additional internal gene duplication event.
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