Sentence examples for required a direct interaction from inspiring English sources

Stimulation of IN DNA binding required a direct interaction between IN and the C-terminus of LEDGF/p75.

This inhibition required a direct interaction between active ERα and BRCA1 (aa 338 379 of ERα) and their co-recruitment on ERE which blocked further ERα recognition by coactivators such as p300., Increasing concentrations of estrogen or overexpression of cyclin D1 which antagonizes and excludes BRCA1, induces estrogen responsive genes.

It is also plausible that AtCRT1a and CRT3 are unable to efficiently fold different Ca2+-releasing components in the ER, or that AtCRT1a and CRT3 fail to interact with these components that may require a direct interaction with CRT to facilitate Ca2+-signaling.

Skeletal-type E-C coupling is thought to require a direct interaction between RyR1 and the α1S-DHPR.

In this paper, we assess the effectiveness of 3D annotations as mechanisms for explicit design intent representation and examine their impact in model alteration processes that require a direct interaction with the model's geometry.

It essentially requires a direct interaction between the nucleus, in particular the nuclear envelope (NE), and the cytoskeleton.

Our present findings provide evidence that the PKC isoform involved in TACE activation is PKCε and that this regulation requires a direct interaction between PKCε and TACE.

This hypothesis does not require a direct interaction between p75 and TrkA.

Altogether, these results strongly suggest the recruitment of LTBP-1 into Notch3-ECD deposits by a co-aggregation mechanism requiring a direct interaction.

Other members of the Arf family, Arl2 and Arl3, have roles in microtubule-related processes but these are not believed to require a direct interaction with tubulin.

Thus, it is possible that the molecular complex between the triadins and Cav-3 requires a direct interaction of Cav-3 with the DHPR.