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A more conservative mortality reduction of 7.5% would require the enrolment of 700 patients per arm.
Such an endeavour, however, would require the enrolment of a large homogeneous cohort of patients in whom cytokine balance, sex hormone levels and outcome could be related to each other and between patients.
These questions require the enrolment of patients in a crossover study and follow-up of PaO2 while the patient is returned to SP. Such a study remains to be done.
With a power of 0.80, type I error of 0.05, and a mortality reduction of 10% in patients treated with CVVH (estimated 60-day mortality in the CVVHD arm 55%), we estimate that such a trial would require the enrolment of nearly 400 patients per arm.
Similar(56)
We analyze these interventions as examples of "value articulation", which we view as a relational and sociomaterial practice that requires the enrolment of people, plants, and things that together perform, spread, and deploy stories about why given places need protection.
The study used a two-stage design requiring the enrolment of 17 patients in the first stage.
The single-stage design required the enrolment of 28 patients; in cases of 24 responses or more the regimen would be considered worthy of further investigations.
To detect a response rate of 15% with a probability of a type I error of 5% and a type II error of 10% required the enrolment of 21 patients in stage 1.
According to Simon, the detection of a PFS6 rate of ⩾47% with a probability of a type I error of 5% and a type II error of 20% required the enrolment of 18 patients in stage one.
Increasing the number of included patients and consequently the number of patients who initiated dialysis would require the extension of the enrolment period beyond 12 months.
Doctors require the largest increase in training enrolment to meet minimum staffing needs within the decade because they have the longest training time.
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