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While they succeeded to an extent, it's important to remember this is still 1.0 technology and it's going to require refinement over time.
Improving pre-clinical models by the research community is one aspect of the drug development pipeline that will continue to require refinement.
Various preclinical studies and clinical trials using these advances have shown that tissue-engineered materials are a viable option for surgical repair, but require refinement if they are going to reach their clinical potential.
Alternatively, the binding-site motif may require refinement.
The general concept of SR-mediated uptake of Gram-positive bacteria via their cell wall LTA, a known SR ligand, may require refinement.
Second, the assumptions underlying our travel time models may require refinement.
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Doing that is likely to require refinements to the protocols for reading the scans and training and education programs for neuroradiologists.
Taken together, our results suggest that roadside fencing can affect behavior, space use, and thermal ecology of tortoises, which may require refinements to future conservation strategies involving roadside fencing.
This in turn may require refinements to the notation system as issues in depicting the relation between components and the cellular components in which they are active arise.
As future programming deepens and widens, good programming skills, child participation, and monitoring and evaluation are areas that require refinements through sharpened programming skills and focus on child well-being-related results.
Evaluation of these agents will therefore require refinements in trial design to robustly detect 'soft' end points such as stable disease, coupled with the development and validation of improved markers for assessing biological activity.
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