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Taken together, these results indicate OS to require pathways commonly deregulated in cancer as well as to feature OS-specific alterations comprising deregulated osteoclast differentiation.
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The necessity of motility and reaction to stimuli additionally requires pathways that quickly and reversibly change cytoskeletal organization.
The dynamic and interactive nature of ChiBE views requires pathways to be automatically drawn.
OS requires pathways commonly deregulated in cancer but also features OS-specific alterations like deregulated osteoclast differentiation.
If we delay the progress towards that required pathway it will become far more painful to do so in the future," he added.
We also put forth a systematic workflow that can be implemented in projects requiring pathway design and highlight current limitations and obstacles in computational pathway design.
Thus, higher productivities might require alternative pathways for NADP+/NADPH recycling.
However, both populations require this pathway in order to give rise to molecular heterogeneity.
CGNPs require Shh pathway activity for proliferation as well as for E2F1 expression.
This suggests that the initial stages of hindgut specification do not require JAK/STAT pathway signalling.
When 4 or more oncogenic mutations are required, mutator pathways predominate.
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