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This is of advantage for applications, which require modulation of pharmacokinetics (PK), yet also need free payload for activity.
Such complexity significantly complicates experiments designed to study pathway function and presents a challenge for developing practical applications that require modulation of one or more pathways.
The antagonistic pleiotropic characteristics of ARF as both tumor and regeneration suppressor imply that inducing epimorphic regeneration clinically would require modulation of ARF –p53 axis activation.
A contact plate method may be difficult to implement or require modulation of the technique for culturing of irregular surfaces [ 6, 10, 21, 27, 29].
Diverse biological conditions, such as ATP-loading during mitochondrial biogenesis or physiological and environmental changes, require modulation of the mitochondrial adenine nucleotide pool size [ 9, 17, 18, 46].
Our good-fit conjunction-task WM connectivity models (Fig. 7A C) require modulation of the extrastriate area via the frontoparietal regions.
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Turning requires modulation of ankle impedance in the sagittal and frontal planes to control lateral and propulsive ground reaction forces in order to accelerate the body center of mass along the gait path, resulting in increased lateral and propulsive impulses when compared to a straight step [3].
Not only does it make for a great poem for recitation requiring modulation of voice and emotions at a dramatic pace, it is also a story of courage.
Cellular growth requires modulation of protein synthesis.
Since HU is able to constrain DNA supercoiling and the regulation of these genes requires modulation of DNA superhelicity, it seemed worthwhile to analyze the HU regulon under this perspective.
However, invasion is a complex process that requires modulation of cellular adhesiveness to the substratum.
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CEO of Professional Science Editing for Scientists @ prosciediting.com