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Furthermore, the non-serous (mucinous, endometrioid and clear cell) subtypes usually are detected in FIGO-stages I-II and therefore represent uncommon diseases which require large scale research trials for searching for subtype specific biomarkers [ 8].
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Numerous current and envisioned applications, e.g. environmental, agricultural, military or research ones, require large-scale WSNs.
The cost of producing novel repellents becomes prohibitive in part because conventional evaluations [15] against a number of arthropods of medical importance require large-scale synthesis of thousands of compounds in the early stages of research and development (R&D).
While these results and interpretations require large-scale studies and independent confirmation, repeated and independent observations by several research groups suggesting breast cancer risk related to these open reading frames underscores the importance of this region.
It will then require large-scale public-private investment in each stage of the energy innovation pipeline - from basic research and development, to applied R&D, demonstration, direct deployment, infrastructure, and education -- eventually on the scale of $50-80 50-80 billionear of federal investment.
In that event, preventing a dynastic society of relentlessly growing inequality would require large-scale redistribution.
The new normal will require large-scale public investment to protect New York from extremist shocks.
Modern scientific collaborations require large-scale integration of various processes.
Being able to do so requires large-scale infrastructure and a critical mass of expertise that very few research centres have.
Drug discovery research, including screening chemical libraries as well as structural and kinetic analyses, requires large-scale caspase-3 preparation.
It also suffers from an "obsession with big-ticket projects" requiring large-scale corporate development.
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