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Drugs frequently require interactions with multiple targets—via a process known as polypharmacology to achieve their therapeutic actions.
Engineering pathways, programs and traits that require interactions of many, often unknown, genes requires advanced engineering strategies in the context of synthetic biology.
They include supply of oxygen to oxygenases and the respiratory chain, particularly under low oxygen conditions; oxygen sensing and modulation of transcription factor activity; and detoxification of NO, and seem to require interactions of VHb with "partner proteins".
Some of the functional features of these engineered VSDs are reminiscent of Kv3.1 channels, indicating that these properties do not require interactions between Kv subunits or between the voltage sensing and the pore domains of Kv channels.
Most of the above processes may require interactions with proteins other than PrP, yet the nature of such interaction partners is largely unknown.
The lack of CD4 T cell help in the CD40-deficient hosts, despite their >50-fold expansion, introduces a new qualitative facet to CD4 help; it suggests that CD4+ T cells require interactions with CD40 and/or co-stimulation molecules in the host APCs [42] in order to differentiate and be fully licensed to mediate helper effects.
Similar(36)
Metabolism would require interaction with the environment.
The report said many roles would be relatively protected, especially in education, the NHS and care industries, along with jobs that require interaction with the public.
All the algorithms discussed above require interaction with the user.
However, they were defective in two functions that require interaction of polymerase with product RNA.
CAS is comprised of large entities and components which require interaction and adoption in performing certain operations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com