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An observational study would require "enrolling sufficient numbers of unvaccinated children and matching them with vaccinated children of the same age, gender, ethnicity, and geographic location — a necessary step to rule out chance findings" and would be prohibitively difficult and time-consuming, if not impossible.
Clinical trials evaluating interventions for infectious diseases require enrolling participants that are vulnerable to infection.
This would require enrolling subjects who are HIV+ and HAART naïve.
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As the inclusion criteria for categories 1 and 2 did not require enrolled patients to have 2+ or more vitreous haze, not all enrolled subjects had the potential to improve two or more steps.
Among the rule-based designs studied, the 5 + 5 a design picks the MTD as accurately as the model based designs for the true DLT rates generated using the chosen log-logistic and linear dose-toxicity curves, but requires enrolling a higher number of patients than the other designs.
To reach a 1.8% significant discrepancy in PTLB rates between pdm flu and uninfected controls (Table 5) with a 3.4% pdm flu CIR (α = 0.05, 1 β = 0.8), it would have required enrolling over 1,800 infected pregnant women in our cohort.
Achieving 'personalized medicine' requires enrolling representative cohorts into genetic studies, but patient self-selection may introduce bias.
In conclusion, we believe that further studies are required, enrolling other ethnic human population groups as well as in vitro assays to reveal the apoptosis pathway, to determine the role of the FAS and FALG gene polymorphisms in HBV infection.
After widespread condemnation in 2014 of the Indonesian police force's use of the practice for recruits, the government said it would no longer require women enrolling at a college for civil servants to undergo the examination.
At the 95% significance level and with 90% power, we would require to enroll 4,007 students.
Detecting a difference in mechanical ventilation requirements of this magnitude might require a RCT enrolling more than 200 patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com