Sentence examples for require disruption from inspiring English sources
Current spine arthroplasty devices require disruption of the annulus fibrosus for implantation.
At present, it is unclear how cycling of NOXO1 between these two states is regulated and what the molecular details of this active state are, but our data suggest that full activation will require disruption of the intramolecular interaction between the tandem SH3 domains and the proline-rich region.
Previous reports indicate that primary human MEC require disruption of multiple pathways for complete transformation [ 37, 51, 35] whereas rodent cells can be transformed by two oncogenes [ 52].
Channel opening may require disruption of this salt bridge network, presumably by the binding of ADP to the three basic residues located on these helices.
To examine the effect of Angptl2 on signaling by canonical Notch ligands would require disruption between Notch and each of these ligands (by knockdown or specific blocking antibodies).
Further statistical method development is expected to lead to substantial improvements in fine-mapping causal regulatory variants, and may illuminate novel mechanisms that do not necessarily require disruption of transcription factor binding [ 34].
The situation with which my story begins required disruption.
The ability of HGF to induce epithelial cell morphological changes and motility requires disruption of cell-to-cell adhesion and dissociation of the basal lamina from the extracellular matrix [13],[13].
This unstable injury requires disruption of the ligaments between the occiput and C1, and commonly results in severe stretch or laceration injury to the upper spinal cord and brainstem [8].
Entry of EEV requires disruption of the outer viral membrane either at the plasma membrane or in endosomes [14], [15], [16].
This observation further supported our above hypothesis that the G protein-mediated inhibition of NMDA channels by DHPG required disruption of the mGluR1a/Homer c-c/Shank3, but not NMDA-R/PSD-95/GKAP complex.
