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Federal prosecutors in Manhattan typically require cooperating witnesses to admit to all previous crimes — even those the government is unaware of — and to stop committing them.
However, known SMAD target promoters seldom contain SBE concatemers, and those that contain up to four SBEs still require cooperating factors for effective DNA binding [ 5].
While the oncogenic capacity of these genes in mammary tissue is clear, the long latencies of c- myc-induced and cyclin D1-induced tumours in particular indicate that, on their own, they are weak oncogenes and may require cooperating oncogenes for efficient carcinogenesis.
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As a hypothetical model, the molecular pathogenesis of AML requires cooperating mutations of several genes such as early mutation, class-I and class-II mutations.
The methods of both studies required cooperating subjects, as baseline comparability was ensured by stimulating to a specific percentage of maximum voluntary contraction (%MVC), 60 and 20% MVC, respectively.
In designing the model, we require that cooperating applications communicate with one another through JAVA RMI (remote method invocation).
The semi-distributed and fully distributed architectures are less sensitive to backhaul unreliability; however, they require all cooperating TNs to be capable of performing precoding or making scheduling decisions.
Indeed, the Pep null allele appears to require a cooperating mutation to develop disease, just as the R620W polymorphism in humans does not act alone.
One possible explanation is that ectopic PMN factors are not sufficient to establish a stable β-like state, a status that might require additional cooperating transcription factors.
The algorithm requiring fewer cooperating CR users while providing an equivalent detection performance is more promising to improve the whole energy efficiency.
However, overexpression of YAP alone does not promote oncogenic growth in mouse mammary glands, suggesting that YAP amplification requires these cooperating lesions to transform cells [78].
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