Sentence examples for require complementarity from inspiring English sources

However, this comparison among places is arguably made easier also because we only require complementarity — marginal gains in variation — rather than total amounts.

Activation requires complementarity to the LDLR promoter and can be achieved by chemically modified duplex RNAs.

MiRNAs canonically recognize targets in 3′UTRs via Watson-Crick base pairing, requiring complementarity with as few as six consecutive nucleotides between the 5′end of a mature miRNAs and the 3′UTR of a target transcript [ 7].

The outcome of the reuse of the binding pocket by multiple distinct binding partners and the required complementarity between binding peptide and the binding pocket results in the repeated patterns that we refer to as motifs.

Translational suppression and mRNA degradation, modes by which mammalian miRNAs regulate gene expression, do not require complete complementarity between the miRNA and target.

However, recent evidence suggest that miRNAs do not require perfect complementarity with target 3′UTRs to induce functional translational repression, and non-canonical interactions are frequent [ 8].

I think one should be more cautious on these issues because known RNAi-based antiviral defense mechanisms require exact complementarity between the siRNA and the target.

These techniques have revealed that some miRNAs can also bind their targets in the coding regions of genes and that other miRNAs do not require base complementarity at all in order to regulate target gene expression [ 33– 33].

Even under this circumstance, it is plausible that these corresponding sites of psiCHECK-2 vector are also repressed by miRNA interference because unlike siRNA, miRNA does not require perfect complementarity of sequences.

However, shorter complementary binding can result in effective RNAi (Lin et al. 2005), and therefore, it is possible that Giardia miRNAs do not require full complementarity to their targets, and a single miRNA may target a number of different UTR regions.

Target interaction does not require perfect complementarity between microRNA and mRNA sequences, although near-perfect base pairing in a small region in the 5′-end (positions 2 8) of the miRNA (sometimes termed "seed") appears to be one of the key determinants of target recognition [ 4].