Contrary to F27, F165 shows a large phylogenetic variability, yet its replacement required additional fine-tuning, probably because of its location in direct vicinity of the conjugated chromophore ring system (Fig. 1).
One possible explanation might be that drastic re-structuring of the regulatory cascades during evolution of the Pasteurellaceae required additional fine tuning of the respiratory metabolism.
However, additional fine tuning may be required, since differentiation of highly specialized cells is generally thought to be strictly regulated with multiple checkpoints.
No additional fine tuning was administered.
They can then fine-tune medications, preventing health crises that require additional hospitalization.
Mentally and emotionally he seems to require no fine-tuning.
Thus, it seems likely that aquatic conditions require less fine-tuning of Rubisco activity by positive selection, compared to terrestrial habitats.
It is conceivable that the interaction is more transient, or else, that it requires additional factors for stabilization, thus allowing for fine-tuning the flow of synaptic vesicles targeted for selective autophagy.
For instance, systems that rely on expensive inducers would opt for modifications that minimize the EC50 value, whereas systems that require fine-tuning would minimize the Hill coefficient.
54 Natural osmotic stress in the soil micro-environment, which tardigrades are subjected to with their whole body surface, may require fine-tuning of water and solute homeostasis.
Prokaryotes widely employ two-component regulatory systems composed of histidine kinase and its cognate response regulator to control various regulatory functions that require fine-tuning of gene expression.
